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Thursday 27 April 2017

Nine Ways to Make Yourself Smarter

Looking for ways to boost your intellect, stave off mental aging, and maybe even live a longer life? You might be surprised to learn that not only do such strategies exist, but many are easily attainable by making simple tweaks here and there to your daily routine. Embracing the strategies that follow may give a hearty boost to your brainpower, help you keep mentally healthy and ultimately even make yourself smarter.

May 17, 2012 

Nine Ways to Make Yourself Smarter

Story at-a-glance

  • You can impact your brain function and cognitive abilities by making simple tweaks here and there to your daily routine
  • Exercise and sound sleep are vital for your brain health, as are certain nutrients, such as omega-3 fats, coconut oil, vitamin B12, vitamin D, probiotics and more
  • Listening to music, challenging your mind, and even surfing the Internet can also give your brain a boost
By Dr. Mercola

Nine Tips for a Smarter You …

1. Exercise
Exercise encourages your brain to work at optimum capacity by causing nerve cells to multiply, strengthening their interconnections and protecting them from damage. During exercise nerve cells release proteins known as neurotrophic factors. One in particular, called brain-derived neurotrophic factor (BDNF), triggers numerous other chemicals that promote neural health, and directly benefits cognitive functions, including learning. Further, exercise provides protective effects to your brain through:
  • The production of nerve-protecting compounds
  • Greater blood flow to your brain
  • Improved development and survival of neurons
  • Decreased risk of cardiovascular diseases such as stroke
A 2010 study on primates published in Neurosciencei also revealed that regular exercise not only improved blood flow to the brain, but also helped the monkeys learn new tasks twice as quickly as non-exercising monkeys, a benefit the researchers believe would hold true for people as well.
Still more research has shown that exercise boosts mitochondria, organelles that produce energy within every cell of your body, which suggests exercise may help your brain work faster and more efficiently.ii
To get the most out of your workouts, I recommend a comprehensive program that includes Peak Fitness high-intensity exercise, strength training, stretching, and core work.
2. Animal-Based Omega-3 Fats
Docosahexaenoic acid, or DHA, an omega-3 fat, is an essential structural component of both your brain and retina. Approximately 60 percent of your brain is composed of fats—25 percent of which is DHA. DHA is also an essential structural ingredient of breast milk, which is believed to be a major reason why breastfed babies consistently score higher on IQ tests than formula-fed babies.
Omega-3 fats such as DHA are considered essential because your body cannot produce it, and must get it from your daily diet. DHA-rich foods include fish, liver, and brain—all of which are no longer consumed in great amounts by most Americans.
DHA is found in high levels in your neurons -- the cells of your central nervous system, where it provides structural support. When your omega-3 intake is inadequate, your nerve cells become stiff and more prone to inflammation as the missing omega-3 fats are substituted with cholesterol and omega-6 instead. Once your nerve cells become rigid and inflamed, proper neurotransmission from cell to cell and within cells become compromised.
The influence of omega-3 fat on physical and mental health has been the subject of intense research over the last four decades, and there's compelling evidence that animal-based omega-3 fats can help reduce the symptoms of a variety of psychiatric illnesses and degenerative brain disorders. For example, low DHA levels have been linked to memory loss and Alzheimer's disease.
Even more exciting is research showing that degenerative conditions can not only be prevented but also potentially reversed. For example, in one study, 485 elderly volunteers suffering from memory deficits saw significant improvement after taking 900 mg of DHA per day for 24 weeks, compared with controls.iii
Another study found significant improvement in verbal fluency scores after taking 800 mg of DHA per day for four months compared with placebo.ivFurthermore, memory and rate of learning were significantly improved when DHA was combined with 12 mg of lutein per day.
Interestingly, research suggests that the unsaturated fatty acid composition of normal brain tissue is age-specific, which could imply that the older you get, the greater your need for animal-based omega-3 fat to prevent mental decline and brain degeneration.
To compensate for our inherently low omega-3 diet, a high quality animal-based omega-3 supplement is something that I recommend for virtually everyone, especially if you're pregnant. I prefer krill oil compared to all other animal-based omega-3's, because while the metabolic effects of krill oil and fish oil are "essentially similar," krill oil is as effective as fish oil despite the fact that it contains less EPA and DHA.v This is because krill oil is absorbed up to 10-15 times as well as fish oil, due to its molecular composition, and is less prone to oxidation (rancidity) because it is naturally complexed with the potent fat-soluble antioxidant astaxanthin.
3. Sleep
Sleep is not only essential for regenerating your physical body, but it is imperative for reaching new mental insights and being able to see new creative solutions to old problems. Sleep removes the blinders and helps "reset" your brain to look at problems from a different perspective, which is crucial to creativity.
Research from Harvard indicates that people are 33 percent more likely to infer connections among distantly related ideas after sleeping, but few realize that their performance has actually improved. Sleep is also known to enhance your memories and help you "practice" and improve your performance of challenging skills. In fact, a single night of sleeping only four to six hours can impact your ability to think clearly the next day.
The process of growth, known as plasticity, is believed to underlie the brain's capacity to control behavior, including learning and memory. Plasticity occurs when neurons are stimulated by events, or information, from the environment. However, sleep and sleep loss modify the expression of several genes and gene products that may be important for synaptic plasticity. Furthermore, certain forms of long-term potentiation, a neural process associated with the laying down of learning and memory, can be elicited in sleep, suggesting synaptic connections are strengthened while you slumber.
As you might suspect, this holds true for infants too, and research shows that naps can give a boost to babies' brainpower. Specifically, infants who slept in between learning and testing sessions had a better ability to recognize patterns in new information, which signals an important change in memory that plays an essential role in cognitive development.vi Even among adults, a mid-day nap was found to dramatically boost and restore brainpower.vii You can find 33 tips to help you get the shut-eye you need here.
4. Coconut Oil
One of the primary fuels your brain needs is glucose, which is converted into energy. Your brain actually manufactures its own insulin to convert glucose in your bloodstream into the food it needs to survive.
If your brain's production of insulin decreases, your brain literally begins to starve, as it's deprived of the glucose-converted energy it needs to function normally. This is what happens to Alzheimer's patients -- portions of their brain start to atrophy, or starve, leading to impaired functioning and eventual loss of memory, speech, movement and personality.
In effect, your brain can begin to atrophy from starvation if it becomes insulin resistant and loses its ability to convert glucose into energy. Fortunately, your brain is able to run on more than one type of energy supply, and this is where coconut oil enters the picture.
There's another substance that can feed your brain and prevent brain atrophy. It may even restore and renew neuron and nerve function in your brain after damage has set in.
The substance in question is called ketone bodies or ketoacids. Ketones are what your body produces when it converts fat (as opposed to glucose) into energy, and a primary source of ketone bodies are the medium chain triglycerides (MCT) found in coconut oil! Coconut oil contains about 66 percent MCTs. Therapeutic levels of MCTs have been studied at 20 grams per day. According to research by Dr. Mary Newport, just over two tablespoons of coconut oil (about 35 ml or 7 level teaspoons) would supply you with the equivalent of 20 grams of MCT, which is indicated as either a preventative measure against degenerative neurological diseases, or as a treatment for an already established case.
Everyone tolerates coconut oil differently, so you may have to start slowly and build up to these therapeutic levels. My recommendation is to start with one teaspoon, taken with food in the mornings. Gradually add more coconut oil every few days until you are able to tolerate four tablespoons. Coconut oil is best taken with food, to avoid upsetting your stomach.
5. Vitamin D
Activated vitamin D receptors increase nerve growth in your brain, and researchers have also located metabolic pathways for vitamin D in the hippocampus and cerebellum of the brain, areas that are involved in planning, processing of information, and the formation of new memories.
The National Institutes of Mental Health recently concluded that it is vital that the mother get enough vitamin D while pregnant in order for the baby's brain to develop properly. The child must also get enough vitamin D after birth for "normal" brain functioning. In older adults, too, research has shown that low vitamin D levels are associated with poorer brain function, and increasing levels may help keep older adults mentally fit.viii
Appropriate sun exposure would take care of these issues, as the sun is irreplaceable when it comes to the body's ability to produce adequate amounts of vitamin D.
Appropriate sun exposure is all it takes to keep your levels where they need to be for healthy brain function. If this is not an option, a safe tanning bed is the next best alternative, followed by a vitamin D3 supplement. It now appears as though most adults need about 8,000 IU's of vitamin D a day in order to get their serum levels above 40 ng/ml, which is the lowest they should be. Ideally, your serum levels should be between 50-70 ng/ml, and up to 100 ng/ml to treat cancer and heart disease. However, it's important to realize that there's no magic dosage when it comes to vitamin D. What's important is your serum level, so you need to get your vitamin D levels tested to make sure you're staying within the optimal and therapeutic ranges as indicated below.
vitamin d levels
6. Optimize Your Gut Flora
Your gut is your "second brain," and your gut bacteria transmits information to your brain via the vagus nerve, the tenth cranial nerve that runs from your brain stem into your enteric nervous system (the nervous system of your gastrointestinal tract). There is a close connection between abnormal gut flora and abnormal brain development, and just as you have neurons in your brain, you also have neurons in your gut -- including neurons that produce neurotransmitters like serotonin, which is also found in your brain and is linked to mood.
Quite simply, your gut health can impact your brain function, psyche, and behavior, as they are interconnected and interdependent in a number of different ways.
Your gut bacteria are an active and integrated part of your body, and as such are heavily dependent on your diet and vulnerable to your lifestyle. If you consume a lot of processed foods and sweetened drinks, for instance, your gut bacteria are likely going to be severely compromised because processed foods in general will destroy healthy microflora and sugars of all kinds feed bad bacteria and yeast. Limiting sugar and processed foods, while eating traditionally fermented foods (rich in naturally occurring good bacteria), taking a probiotic supplement and breastfeeding your baby are among the best ways to optimize gut flora and subsequently support brain health.
7. Vitamin B12
Vitamin B12, or rather a lack thereof, has been called the "canary in the coalmine" for your future brain health, and recent research has bolstered the importance of this vitamin in keeping your mind sharp as you age. According to the latest research, people with high levels of markers for vitamin B12 deficiency were more likely to score lower on cognitive tests, as well as have a smaller total brain volume,ix which suggests a lack of the vitamin may contribute to brain shrinkage.
Mental fogginess and problems with memory are two of the top warning signs that you have vitamin B12 deficiency, and this is indicative of its importance for your brain health.
In addition, a Finnish study found that people who consume foods rich in B12 may reduce their risk of Alzheimer's in their later years.x For each unit increase in the marker of vitamin B12 (holotranscobalamin) the risk of developing Alzheimer's was reduced by 2 percent. Research also shows that supplementing with B vitamins, including B12, helps to slow brain atrophy in elderly people with mild cognitive impairment (brain atrophy is a well-established characteristic of Alzheimer's disease).xi
Vitamin B12 deficiency is widespread and many have trouble absorbing this nutrient properly from food sources. Blood tests for vitamin B12 are not always a reliable indicator of B12 status, so watching for symptoms of deficiency and increasing your dietary and supplemental intake is a practical alternative to blood testing.
B12 is available in its natural form only in animal food sources. These include seafood, beef, chicken, pork, milk, and eggs. If you don't consume enough of these animal products (and I don't recommend consuming seafood unless you know it is from a pure water source) to get an adequate supply of B12, or if your body's ability to absorb the vitamin from food is compromised, vitamin B12 supplementation is completely non-toxic and inexpensive, especially when compared to the cost of laboratory testing. I recommend an under-the-tongue fine mist spray, as this technology helps you absorb the vitamin into the fine capillaries under your tongue.
8. Listen to Music
It's long been theorized that listening to music may boost your brainpower; you've probably heard of this with the "Mozart Effect," which suggests listening to classical music can make you smarter. Indeed, research has shown that listening to music while exercising boosted cognitive levels and verbal fluency skills in people diagnosed with coronary artery disease (coronary artery disease has been linked to a decline in cognitive abilities). In this study, signs of improvement in the verbal fluency areas more than doubled after listening to music compared to that of the non-music session.xii
Listening to music has also been associated with enhanced cognitive functioning and improved mental focus among healthy adults, so take advantage of this simple pleasure whenever you can.
9. Challenge Your Mind
One of the simplest methods to boost your brain function is to keep on learning. The size and structure of neurons and the connections between them actually change as you learn. This can take on many forms above and beyond book learning to include activities like traveling, learning to play a musical instrument or speak a foreign language, or participating in social and community activities.
Another important method? Brain aerobics. As with learning, challenging your brain with mind-training exercises can keep your brain fit as you age. This can be something as simple as thinking of famous people whose first names begin with the letter A, doing crossword puzzles or playing board games that get you thinking. Research has even shown that surfing the Web activates regions in your brain related to decision-making and complex reasoning.xiii So unlike passively watching TV, using the Internet is an engaging task that may actually help to improve your brainpower.
References:

http://articles.mercola.com/sites/articles/archive/2012/05/17/good-brain-health-tips.aspx

Tuesday 25 April 2017

The Importance of B Vitamins for Brain Health and Combating Dementia

A number of studies have investigated the impact of vitamin supplementation to prevent and/or treat cognitive dysfunction and decline.
It's well-established that healthy fats such as animal-based omega-3 fats are really important for brain health, but other nutrients such as vitamins are also necessary for optimal brain function.
March 17, 2016 

Story at-a-glance

  • Recent research found that giving a multivitamin supplement to seniors suffering from mild cognitive impairment and depression helped improve both conditions
  • Compared to placebo, seniors with high omega-3 levels who were given high doses of vitamins B6, folic acid (B9) and B12 experienced a 40 percent reduced brain atrophy rate over the 2-year treatment course
  • Not only do B vitamins slow brain shrinkage, but they specifically slow shrinkage in brain regions known to be most severely impacted by Alzheimer's disease

By Dr. Mercola
A number of studies have investigated the impact of vitamin supplementation to prevent and/or treat cognitive dysfunction and decline.
It's well-established that healthy fats such as animal-based omega-3 fats are really important for brain health, but other nutrients such as vitamins are also necessary for optimal brain function.
Most recently, a Korean study1 concluded that giving a multivitamin supplement to seniors suffering from mild cognitive impairment and depression helped improve both conditions.
B vitamins in particular, especially folate (B9, aka folic acid in its synthetic form) and vitamins B6 and B12, have made headlines for their powerful role in preventing cognitive decline and more serious dementia such as Alzheimer's disease.
Mental fogginess and problems with memory are actually two of the top warning signs that you have vitamin B12 deficiency, indicating its importance for brain health.

B Vitamins and Omega-3 — An Important Combo for Brain Health

Although Dr. Michael Greger's video is a good review on the research about B vitamins, being a vegetarian he does not include information about animal-based omega-3 fats, which are also beneficial in reducing dementia.

Low plasma concentrations of omega-3 and high levels of the amino acid homocysteine are associated with brain atrophy, dementia, and Alzheimer's. Vitamins B6, B9, and B12 help convert homocysteine into methionine — a building block for proteins.
If you don't get enough of these B vitamins, this conversion process is impaired and as a result your homocysteine levels increase. Conversely, when you increase intake of folic acid (folate), vitamin B6, and vitamin B12, your homocysteine levels decrease.
In one placebo-controlled trial2 published in 2015, 168 seniors diagnosed with mild cognitive impairment were randomly assigned to receive either placebo, or daily supplementation with 0.8 mg of folic acid, 20 mg of vitamin B6, and 0.5 mg of B12.
It's worth noting that these are quite high doses — far above the U.S. RDA. All participants underwent cranial magnetic resonance imaging (MRI) scans at the outset of the study, and at the end, two years later.
The effect of the vitamin B supplementation was analyzed and compared to their omega-3 fatty acid concentrations at baseline. Interestingly, only those who had high omega-3 levels reaped beneficial effects from the B vitamins.
As noted by the authors:
"There was a significant interaction between B vitamin treatment and plasma combined omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) on brain atrophy rates.
In subjects with high baseline omega-3 fatty acids (>590 μmol/L), B vitamin treatment slowed the mean atrophy rate by 40 percent compared with placebo.
B vitamin treatment had no significant effect on the rate of atrophy among subjects with low baseline omega-3 fatty acids (<390 μmol/L). High baseline omega-3 fatty acids were associated with a slower rate of brain atrophy in the B vitamin group but not in the placebo group...
It is also suggested that the beneficial effect of omega-3 fatty acids on brain atrophy may be confined to subjects with good B vitamin status."

B Vitamins Significantly Slow Brain Shrinkage

As mentioned above, elevated homocysteine is linked to brain degeneration, and B vitamins are known to suppress homocysteine.
A 2010 study,3 in which participants again received higher than normal doses of B vitamins, also found that people receiving B vitamins experienced far less brain shrinkage than the placebo group.
Here the participants received either a placebo or 800 micrograms (mcg) folic acid, 500 mcg B12, and 20 mg B6. The study was based on the presumption that by controlling homocysteine levels you might be able to reduce brain shrinkage, thereby slowing the onset of Alzheimer's.
Indeed, after two years those who received the vitamin B regimen suffered significantly less brain shrinkage compared to those who had received a placebo. Those who had the highest levels of homocysteine at the start of the trial experienced brain shrinkage at half the rate of those taking a placebo.

Research Shows B Vitamins Specifically Slow Alzheimer's Disease

A 2013 study4 takes this research a step further, showing that not only do B vitamins slow brain shrinkage, but they specifically slow shrinkage in brain regions known to be most severely impacted by Alzheimer's disease. Moreover, in those specific areas the shrinkage is decreased by as much as seven-fold!
The brain scans clearly show the difference between placebo and vitamin supplementation on brain atrophy. As in the studies above, participants taking high doses of folic acid and vitamins B6 and B12 lowered their blood levels of homocysteine, and brain shrinkage was decreased by as much as 90 percent.
As noted by the authors:
" … B vitamins lower homocysteine, which directly leads to a decrease in GM [gray matter] atrophy, thereby slowing cognitive decline.
Our results show that B vitamin supplementation can slow the atrophy of specific brain regions that are a key component of the AD [Alzheimer's disease] process and that are associated with cognitive decline."

B12-Rich Foods Reduce Risk of Alzheimer's in Later Years

Other supporting research includes a small Finnish study5 published in 2010. It found that people who consume vitamin B12-rich foods may reduce their risk of Alzheimer's in their later years.
For each unit increase in the marker of vitamin B12 (holotranscobalamin), the risk of developing Alzheimer's was reduced by 2 percent. This makes a strong case for ensuring your diet includes plenty of B vitamin foods, such as meat, poultry, eggs, dairy products and wild-caught fish.
Leafy green vegetables, beans, and peas also provide some of the B vitamins, but if you eat an all vegetarian or vegan diet, you're at a significantly increased risk of vitamin B12 deficiency, as B12 is naturally present in foods that come from animals, including meat, fish, eggs, milk and milk products.
In such a case, supplementation is really important. Another concern is whether your body can adequately absorb the B12. It's the largest vitamin molecule we know of, and because of its hefty size, it's not easily absorbed.
This is why many, if not most, oral B12 supplements fail to deliver any benefits. Vitamin B12 requires a gastric protein called intrinsic factor to bind to it, which allows it to be absorbed in the end of your small intestine (terminal ileum). The intrinsic factor is absorbed first, pulling the attached B12 molecule along with it.
As you grow older, your ability to produce intrinsic factor decreases, thereby increasing your risk for vitamin B12 deficiency. Use of metformin (Glucophage, Glucophage XR, Fortamet, Riomet, and Glumetza) may also inhibit your B12 absorption, especially at higher doses. Drinking four or more cups of coffee a day can reduce your B vitamin stores by as much as 15 percent, and use of antacids will also hinder your body's ability to absorb B12.

Other Valuable Vitamins for Brain Health

Besides B vitamins, vitamins C and D are also important for optimal brain health.6 Vitamin C plays a role in the production of neurotransmitters, including serotonin, which has antidepressant activity. Vitamin C has also been shown to improve IQ, memory, and offer protection against age-related brain degeneration and strokes.
In one study,7 the combination of vitamin C and E (which work synergistically) helped reduce the risk of dementia by 60 percent. Vitamin C also has detoxifying effects, and due to its ability to cross your blood-brain barrier, it can help remove heavy metals from your brain.
Vitamin D, a steroid hormone produced in your skin in response to sun exposure, also has profound effects on your brain. Pregnant women need to be particularly cognizant of this, as vitamin D deficiency during pregnancy can prevent proper brain development in the fetus, plus a host of other problems. After birth, children need vitamin D for continued brain development, and in adulthood, optimal levels have been shown to help prevent cognitive decline.8,9

Where to Find These Valuable Brain Nutrients

There's nothing "normal" about cognitive decline. More often than not, it's due to poor lifestyle choices, starting with a nutrient-deficient diet that is too high in sugars, non-vegetable carbs, unhealthy fats like trans fats, and too many toxins (pesticides and artificial additives, etc).
As a general rule, I recommend getting most if not all of your nutrition from REAL FOOD, ideally organic to avoid toxic pesticides, and locally grown. Depending on your situation and condition however, you may need one or more supplements.
To start, review the following listing of foods that contain the brain nutrients discussed in this article: animal-based omega-3s, vitamins B6, B9, and B12, C, and D. If you find that you rarely or never eat foods rich in one or more of these nutrients, you may want to consider taking a high-quality, ideally food-based supplement. I've made some suggestions to keep in mind when selecting a good supplement.
NutrientDietary SourcesSupplement Recommendations
Animal-based omega-3Fatty fish that is low in mercury, such as wild-caught Alaskan salmon, sardines, and anchovies, as well as organic grass-fed beef.10 

Sardines, in particular, are one of the most concentrated sources of omega-3 fats, with one serving containing more than 50 percent of your recommended daily value.
Antarctic krill oil is a sustainable choice. It also has the added benefit of containing natural astaxanthin, which helps prevent oxidation.

Another good option is wild-caught Alaskan salmon oil.
Vitamin B6Turkey, beef, chicken, wild-caught salmon, sweet potatoes, potatoes, sunflower seeds, pistachios, avocado, spinach and banana.11,12Nutritional yeast is an excellent source of B vitamins, especially B6.13 One serving (2 tablespoons) contains nearly 10 mg of vitamin B6.

Not to be confused with Brewer's yeast or other active yeasts, nutritional yeast is made from an organism grown on molasses, which is then harvested and dried to deactivate the yeast.

It has a pleasant cheesy flavor and can be added to a number of different dishes. For tips, see this vegan blog post.14
Folate (B9)Fresh, raw, and organic leafy green vegetables, especially broccoli, asparagus, spinach, and turnip greens, and a wide variety of beans, especially lentils, but also pinto beans, garbanzo beans, navy and black beans, and kidney beans.15Folic acid is a synthetic type of B vitamin used in supplements; folate is the natural form found in foods. 

Think: folate comes from foliage (edible leafy plants). 

For folic acid to be of use, it must first be activated into its biologically active form — L-5-MTHF. 

This is the form able to cross the blood-brain barrier to give you the brain benefits noted. 

Nearly half of the population has difficulty converting folic acid into the bioactive form due to a genetic reduction in enzyme activity.

For this reason, if you take a B vitamin supplement, make sure it contains natural folate rather than synthetic folic acid. 

Nutritional yeast is an excellent source.16
Vitamin B12Vitamin B12 is found almost exclusively in animal tissues, including foods like beef and beef liver, lamb, snapper, venison, salmon, shrimp, scallops, poultry, eggs, and dairy products. 

The few plant foods that are sources of B12 are actually B12 analogs that block the uptake of true B12.

Also consider limiting sugar and eating fermented foods. 

The entire B group vitamin series is produced within your gut, assuming you have healthy gut flora. 

Eating real food, ideally organic, along with fermented foods will provide your microbiome with important fiber and beneficial bacteria to help optimize your internal vitamin B production.
Nutritional yeast is also high in B12, and is highly recommended for vegetarians and vegans.

One serving (2 tbsp) provides nearly 8 micrograms (mcg) of natural vitamin B12.17

Sublingual (under-the-tongue) fine mist spray or vitamin B12 injections are also effective, as they allow the large B12 molecule to be absorbed directly into your bloodstream.
Vitamin CSweet peppers, chili peppers, Brussel sprouts, broccoli, artichoke, sweet potato, tomato, cauliflower, kale, papaya, strawberries, oranges, kiwifruit, grapefruit, cantaloupe, and lemon.

To boost your intake of fruits and vegetables, consider juicing. As an alternative, you can also make fermented vegetables at home.

The vitamin C in sauerkraut (fermented cabbage) is about six times higher than in the same helping of unfermented cabbage, so it's an excellent way to boost your vitamin C intake.
The most effective form of oral vitamin C is liposomal vitamin C. 

It's not associated with many of the complications of traditional vitamin C or ascorbic acid (such as gastrointestinal distress), which will allow you to achieve higher intracellular concentrations.

You can expect a significant rise in plasma vitamin C concentration at doses between 30 and 100 mg/day.

Taking vitamin C frequently throughout the day is more effective than taking one large dose once a day.
Vitamin DVitamin D is created naturally when your skin is exposed to sunshine.

While you can get some vitamin D from grass-fed meats and other whole foods and fortified foods, sun exposure is an ideal primary source.
When taking supplemental vitamin D, also be sure to increase your intake of vitamin K2 and magnesium, either from food or a supplement.
http://articles.mercola.com/sites/articles/archive/2016/03/17/vitamin-b-brain-health.aspx